Aptamer-Gated Nanoprobes

A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through
nanopore actuation. The new platform engineers together, a highly selective molecular recognition
element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept,
aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of
ATP concentrations at a wide linear range from 100 μM up to 2 mM.
Analyst, 2016,141, 2595-2599, DOI: 10.1039/C6AN00273K