PUBLICATIONS

 

28 Jul



By Tom

A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through
nanopore actuation. The new platform engineers together, a highly selective molecular recognition
element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept,
aptamer gated silica nanoparticles have been successfully used as a sensing platform for t...

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27 Jul



By Tom

Bovine serum albumin (BSA) adsorption measurements were used as a model test to investigate the anti-biofouling performance of hybrid poly(siloxane-urethane) coatings. Different coatings were obtained from isophorone diisocyanate trimer, polycaprolactone triol and hydroxy-terminated poly(dimethylsiloxane). The copolymers showed a phase separated structure that depended on the mixing time and casting temperature. The phase separated structure resu...

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21 Jul



By Tom

This paper describes an aptamer-based optomagnetic biosensor for detection of a small molecule based on target binding-induced inhibition of magnetic nanoparticle (MNP) clustering. A commercial Blu-ray optical pickup unit is used for optical signal acquisition, which enables the establishment of a low-cost and miniaturized biosensing platform. This successful proof-of-concept indicates that our optomagnetic aptasensor can be further develope...

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19 Jul



By Tom

This report describes a membrane barrier whose permeability is modulated through the recognition of a small-molecule target, adenosine triphosphate (ATP), by a DNA-aptamer. The gating function of the DNA-aptamer in the stimulus-responsive membrane was shown to be specific, concentration dependent, and reversible.
Chem. Commun., 2015,51, 5471-5474, DOI: ...

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