DNA-aptamers are used as specific, reversible, and target-concentration dependent actuators in membranes and particles whose permeability or controlled release can be modulated through a molecular recognition event rather than a bulk stimulus. Such membranes and particles find a great application potential in biomedical and bioanalytical flow devices.
We study the function of DNA-based systems in non-conventional solvents such as ionic liquids.
Our interest lies in a fundamental molecular understanding and in pushing the application of functional DNA further toward non-physiological applications.
Ionic liquids are tuneable additives in polymer matrices that can result in unique morphological changes of the membrane polymer. We try to comprehend the underlying molecular interactions and determine the potential of these unique solvents for creating membrane barriers.
Using state-of-the-art surface sensitive techniques, we characterize and study membrane surface modifications and membrane fouling in microfluidic systems.